Protein name:
Membrane cofactor protein ;
Alternative:
CD:
CD46 ;
Organism:
Pig (Sus scrofa).
General Annotation
Sub Unit:
Interacts with C3b and C4b.
Function:
Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. May act as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity.
Subcellular Location:
Cytoplasmic vesicle
secretory vesicle
acrosome inner membrane
Single-pass type I membrane protein
Inner acrosomal membrane of spermatozoa.
Protein Attributes:
50:
MMAFCALRKA | LPCRPENPFS | SRCFVEILWV | SLALVFLLPM | PSDACDEPPK |
100:
FESMRPQFLN | TTYRPGDRVE | YECRPGFQPM | VPALPTFSVC | QDDNTWSPLQ |
150:
EACRRKACSN | LPDPLNGQVS | YPNGDMLFGS | KAQFTCNTGF | YIIGAETVYC |
200:
QVSGNVMAWS | EPSPLCEKIL | CKPPGEIPNG | KYTNSHKDVF | EYNEVVTYSC |
250:
LSSTGPDEFS | LVGESSLFCI | GKDEWSSDPP | ECKVVKCPYP | VVPNGEIVSG |
300:
FGSKFYYKAE | VVFKCNAGFT | LHGRDTIVCG | ANSTWEPEMP | QCIKDSKPTD |
350:
PPATPGPSHP | GPPSPSDASP | PKDAESLDGG | IIAAIVVGVL | AAIAVIAGGV |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Bovine
Mouse
Rat
Pig
ELISA Kit for Pig Membrane cofactor protein
ELISA Kit for Pig Membrane cofactor protein
ELISA Kit for Pig Membrane cofactor protein
ELISA Kit for Pig Membrane cofactor protein
ELISA Kit for Pig Membrane cofactor protein
CLIA Kit for Pig Membrane cofactor protein
CLIA Kit for Pig Membrane cofactor protein
CLIA Kit for Pig Membrane cofactor protein
CLIA Kit for Pig Membrane cofactor protein
CLIA Kit for Pig Membrane cofactor protein
Polyclonal Antibody for Pig Membrane cofactor protein
Polyclonal Antibody for Pig Membrane cofactor protein
Polyclonal Antibody for Pig Membrane cofactor protein
Polyclonal Antibody for Pig Membrane cofactor protein
Polyclonal Antibody for Pig Membrane cofactor protein
Monoclonal Antibody for Pig Membrane cofactor protein
Monoclonal Antibody for Pig Membrane cofactor protein
Monoclonal Antibody for Pig Membrane cofactor protein
Monoclonal Antibody for Pig Membrane cofactor protein
Monoclonal Antibody for Pig Membrane cofactor protein
Protein for Pig Membrane cofactor protein
Protein for Pig Membrane cofactor protein
Protein for Pig Membrane cofactor protein
Protein for Pig Membrane cofactor protein
Protein for Pig Membrane cofactor protein
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);FUNCTION;TISSUE SPECIFICITY
tissue :
Aortic endothelium .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 45-72;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;FUNCTION;GLYCOSYLATION AT ASN-60
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY