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Index > Protein center > CD46(Gene name) > Pig
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  • CD46 (Gene name),
  • Membrane cofactor protein (Protein name ),  MCP_PIG from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    CD46(MCP);
    Protein name:
    Membrane cofactor protein;
    Alternative:

    CD:
    CD46;
    Organism:
    Pig (Sus scrofa). 
    General Annotation
    Sub Unit:
    Interacts with C3b and C4b.
    Function:
    Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. May act as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity.
    Subcellular Location:
    Cytoplasmic vesicle secretory vesicle acrosome inner membrane Single-pass type I membrane protein Inner acrosomal membrane of spermatozoa.
    Protein Attributes:
    Sequence length:
    363
    Sequence:
    50:
    MMAFCALRKA | LPCRPENPFS | SRCFVEILWV | SLALVFLLPM | PSDACDEPPK | 
    100:
    FESMRPQFLN | TTYRPGDRVE | YECRPGFQPM | VPALPTFSVC | QDDNTWSPLQ | 
    150:
    EACRRKACSN | LPDPLNGQVS | YPNGDMLFGS | KAQFTCNTGF | YIIGAETVYC | 
    200:
    QVSGNVMAWS | EPSPLCEKIL | CKPPGEIPNG | KYTNSHKDVF | EYNEVVTYSC | 
    250:
    LSSTGPDEFS | LVGESSLFCI | GKDEWSSDPP | ECKVVKCPYP | VVPNGEIVSG | 
    300:
    FGSKFYYKAE | VVFKCNAGFT | LHGRDTIVCG | ANSTWEPEMP | QCIKDSKPTD | 
    350:
    PPATPGPSHP | GPPSPSDASP | PKDAESLDGG | IIAAIVVGVL | AAIAVIAGGV | 
    363:
    YFFHHKYNKK | RSK
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Pig Membrane cofactor protein
    Cat.:
    E1275h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Pig Membrane cofactor protein
    Cat.:
    E1275b
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    Please sign in first.
    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Pig Membrane cofactor protein
    Cat.:
    E1275m
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Pig Membrane cofactor protein
    Cat.:
    E1275r
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Pig Membrane cofactor protein
    Cat.:
    E1275p
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Pig Membrane cofactor protein
    Cat.:
    U1275h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Pig Membrane cofactor protein
    Cat.:
    U1275m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Pig Membrane cofactor protein
    Cat.:
    U1275r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Pig Membrane cofactor protein
    Cat.:
    U1275b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Pig Membrane cofactor protein
    Cat.:
    U1275p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Pig Membrane cofactor protein
    Cat.:
    P1275Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Pig Membrane cofactor protein
    Cat.:
    P1275Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Pig Membrane cofactor protein
    Polyclonal Antibody for Pig Membrane cofactor protein
    Polyclonal Antibody for Pig Membrane cofactor protein
    Cat.:
    P1275Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Pig Membrane cofactor protein
    Monoclonal Antibody for Pig Membrane cofactor protein
    Monoclonal Antibody for Pig Membrane cofactor protein
    Monoclonal Antibody for Pig Membrane cofactor protein
    Monoclonal Antibody for Pig Membrane cofactor protein
    Protein for Pig Membrane cofactor protein
    Protein for Pig Membrane cofactor protein
    Protein for Pig Membrane cofactor protein
    Protein for Pig Membrane cofactor protein
    Protein for Pig Membrane cofactor protein

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Molecular cloning of a pig homologue of membrane cofactor protein (CD46)."
      Toyomura K. , Fujimura T. , Murakami H. , Natsume T. , Shigehisa T. , Inoue N. , Takeda J. , Kinoshita T.
      Int. Immunol.9:869-876(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);FUNCTION;TISSUE SPECIFICITY
      tissue: Aortic endothelium.
    2. 2.
      "Purification and characterization of the pig analogue of human membrane cofactor protein (CD46/MCP)."
      van den Berg C.W. , Perez de la Lastra J.M. , Llanes D. , Morgan B.P.
      J. Immunol.158:1703-1709(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 45-72;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;FUNCTION;GLYCOSYLATION AT ASN-60
    3. 3.
      "Distribution of membrane cofactor protein (MCP/CD46) on pig tissues. Relevance To xenotransplantation."
      Perez de la Lastra J.M. , Hanna S.M. , Morgan B.P.
      Immunology98:144-151(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
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